Spanish researchers report that the uterine lining or endometrium plays a small but significant role in reducing fertility in overweight women, reports Reuters Health.
The results, they say, show that overweight and obese women who undergo egg fertilization treatments from donors should try to lose weight before becoming pregnant because they are more likely to succeed.
Obese women are known to become more pregnant and have an increased risk of pregnancy loss. Excess weight can affect the ovaries in egg production or the endometrium when the fertilized egg is implanted.
In order to investigate the role of the endometrium, the specialists analyzed 2,656 women who were doing fertilization treatments with ova from normal-weight donors. The researchers observed that as the body mass index increases, the success rate decreases. The percentage of pregnancies that have withstood more than 20 weeks in women with normal weight and underweight was 7.2% higher than in overweight and obese women.
Pregnancy and ectopic pregnancy (the fertilized egg settles outside the uterus) are also closely related to body mass index.
The specialists had to observe two important things, namely that the excess weight has a negative influence on the ovarian and extraovarian activity and its correction could increase the success rate of the fertilization treatments in the overweight or obese women. They also added that the role of the endometrium seems to be a small one, but it should be considered.
September 10, 2007