You can avoid the transmission of hereditary diseases by preimplantation genetic diagnosis

You can avoid the transmission of hereditary diseases by preimplantation genetic diagnosis

You can avoid the transmission of hereditary diseases by preimplantation genetic diagnosis

When a couple wants to conceive a child, they certainly think about the features that the little boy will inherit. Whether it will have the eyes of the mother, the father's nose, blond or brown hair, all these are hereditary characteristics that are transmitted through the genetic material of the parents.

However, the genetic baggage also influences the health of the future child, which is why it is important to consider from the beginning including the transmission of hereditary diseases. Fortunately, for couples who are going through a Vitro Fertilization process, there are pre-packaged diagnostic methods that can early on report such irregularities.

Preimplantation genetic diagnosis (PGD) is an additional technique in IVF procedures, whereby patients at risk of transmitting a genetic disease can prevent its transmission to the future child. A chromosome has thousands of genes, each of them carrying genetic information. The pre-implant diagnosis analyzes the embryos obtained by in vitro fertilization, tracking those genes specific to the diseases concerned. Thus, by realizing it before the embryo transfer, the chances of transferring an affected embryo to the next mother are greatly reduced.

When should you consider a GDP analysis?

All women have a risk of having children with chromosomal abnormalities, but this risk increases markedly with age. If the mother is over 35, the risk of pregnancy in an embryo with an abnormal number of chromosomes is increased. In their case, PGD gives them a greater chance of avoiding the transmission of genetic diseases to the future child.

Also, 50% of first trimester abortions are caused by chromosomal abnormalities, which is why this diagnosis is recommended for patients with a history of spontaneous abortions.

Preimplant genetic diagnosis is also recommended for patients who have a history of pregnancy with an aneuploidy, those who have had several failed Vitro Fertilization procedures, couples with partners carrying monogenic diseases or chromosome structure aberrations, as well as patients who have infertility problems due to low sperm count.

"At the global level, the choice of embryos for embryo transfer is based on well-defined morphological criteria. However, the rate of pregnancies and implicitly the number of children born is not extremely satisfactory, reducing it either due to repeated failures to implant the embryos. either because of spontaneous abortions that can be based on multiple causes, including genetic ones.

Two methods have been developed:

PGD ​​- pre-implantation genetic diagnosis

PGS - pre-implantation genetic screening

PGD ​​is important for patients with a history of genetic defects in the family leading to the transmission of these defects to offspring, causing certain genetic diseases such as: hemophilia, muscular dystrophy, Huntington's disease, cystic fibrosis, Toy-Sachs disease, Down syndrome, etc. told by Monica Dascalescu - principal biologist, senior embryologist at the IVF Academy

Your task is priceless! It is very important that both before conception, and during the next nine months, you will benefit from a detailed monitoring. Because, IVF Academy It offers you the perfect mix between the latest technologies, the latest medical analyzes, a warm atmosphere and a team of dedicated doctors!

About the IVF Academy

The IVF Academy is a Column Medical Center project. It aims to find solutions and transform parents facing infertility issues into happy families, but also to educate the public so that reproductive health becomes a concern, an aspect of life that should not be neglected but treated with care and attention.

The IVF Academy brought together 12 specialists, including 3 out of 5 senior embryologists from Romania. Therefore, it has a success rate of 43.8%, when the success rate of assisted human reproduction procedures is at European level at about 33.8%. The Academy supports a personalized multidisciplinary approach, providing access to specialists from various fields, such as psychologists, endocrinologists or nutritionists.